Synonym:
1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
Properties:
| Related Categories |
Additional Standards,
Analytical Standards,
Analytical/Chromatography,
Chromatography,
Pharmaceutical Secondary Standards,
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grade
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certified reference material
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pharmaceutical secondary standard
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InChI Key
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MCCACAIVAXEFAL-UHFFFAOYSA-N
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form
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neat
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format
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neat
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pharmacopeia traceability
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traceable to BP 253
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traceable to PhEur M1900000
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traceable to USP 1443500
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Description:
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).
Values of analytes vary lot to lot.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAA8995 in the slot below. This is an example certificate only and may not be the lot that you receive.
Safety:
Symbol

GHS07
Hazard statements
H302-H317
Precautionary statements
P280
RIDADR
NONH for all modes of transport