| Specificity | ThisantibodybelongstoCD34(assignedbytheThirdInternationalWorkshoponLeukocyteDifferentiationAntigens,Oxford,1987;Hogg&Horton,1987).Itreactswitha120kDglycoproteinfoundonProgenitorcellpopulationsinhumanbonemarrowandfoetalliver(Katzetal.,1985).Thisantigenisnormallyrestrictedtoimmaturehumanhaemopoieticprecursorcells(Peschel&Koller,1989).
  Cellreactivity(Tindleetal.,1985):
  Normal:Noreactionwithnormalperipherallymphocytes,granulocytes,monocytes,erythrocytesandplatelets.Reactswith<4% of="" cells="" in="" normal="" bone="" marrow.="">4%>
  Clinical:Reaction
  Acutemyeloidleukemia(AML,M1andM2)positive
  Nulllymphoblasticleukemia(NullALL)positive
  Commonacutelymphoblasticleukemia(CALL)positive
  Myeloblasticandlymphoblasticcrisesofchronic
  granulocyticleukemia(CGL)positive
  Chronicmyeloidleukemia(CML)negative
  Tcellacutelymphoblasticleukemia(TALL)negative
  Bcellacutelymphoblasticleukemia(BALL)negative
  Chroniclymphocyticleukemia(CLL)negative
  Celllines:
  ReactswithearlymyeloblastlineKG1.Noreactionwithnull,BorTlymphoid,erythroidorlatermyeloidcelllines. |