| Immunogen | Myelinproteolipidprotein,syntheticpeptideCGRGTKFcorrespondingtotheC-terminalpeptide. | 
| Epitope | C-terminus | 
| Clone | PLPC1 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Reactswithmyelinproteolipidproteininmanymammalianspecies.Showscross-reactivitytoDM20. | 
| Isotype | IgG2a | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesatransmembraneproteolipidproteinthatisthepredominantmyelinproteinpresentinthecentralnervoussystem.Itmayplayaroleinthecompaction,stabilization,andmaintenanceofmyelinsheaths,aswellasinoligodendrocytedevelopmentandaxonalsurvival.MutationsinthisgenecauseX-linkedPelizaeus-Merzbacherdiseaseandspasticparaplegiatype2.Alternativelysplicedtranscriptvariantsencodingdistinctisoformsorhavingdifferent5"UTRs,havebeenidentifiedforthisgene. | 
| GeneSymbol |  | 
| PurificationMethod | ProteinAPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P60201#Thisisthemajormyelinproteinfromthecentralnervoussystem.Itplaysanimportantroleintheformationormaintenanceofthemultilamellarstructureofmyelin. SIZE:277aminoacids;30,077Da SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. PTM:Lipoprotein,Palmitate DISEASE:DefectsinPLP1arethecauseofPelizaeus-Merzbacherdisease(PMD)[MIM:312080].PMDisanX-linkedneurologicdisorderofmyelinmetabolism.Itischaracterizedbyearlyimpairmentofmotordevelopment(duringthefirstthreemonthsoflife)and,later,bythedevelopmentofabnormalmovementsandprogressivespasticparaplegia. SIMILARITY:Belongstothemyelinproteolipidproteinfamily. | 
| MolecularWeight | 23-25kDa |