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Millipore/MAB365 | Anti-Nerve Growth Factor Receptor Antibody, extracellular, clone 192-IgG/MAB365/50 µg
  • Millipore/MAB365 | Anti-Nerve Growth Factor Receptor Antibody, extracellular, clone 192-IgG/MAB365/50 µg

Millipore/MAB365 | Anti-Nerve Growth Factor Receptor Antibody, extracellular, clone 192-IgG/MAB365/50 µg

價(jià)格: ￥4188.00 市場(chǎng)價(jià): 6980.00
貨號(hào): MAB365
品牌: Millipore
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    • Description
      CatalogueNumberMAB365
      Replaces04-1111
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-NerveGrowthFactorReceptorAntibody,extracellular,clone192-IgG
      AlternateNames
      • CD271antigen
      • Lowaffinityneurotrophinreceptorp75NTR
      • Low-affinitynervegrowthfactorreceptor
      • NGFreceptor
      • lowaffinitynervegrowthfactorreceptor
      • nervegrowthfactorreceptor
      • nervegrowthfactorreceptor(TNFRsuperfamily,member16)
      • p75ICD
      BackgroundInformationThelowaffinityNGFR(Nervegrowthfactorreceptor)isa75kDamembrane-spanningglycoproteinlackingintrinsictyrosinekinaseactivity.p75NGFRinteractswithTrkA,thehighaffinityNGFreceptorandpotentiatesTrkAsignalingatlowNGFconcentrations.Thep75receptorbindsnervegrowthfactor,brain-derivedneurotrophicfactor,neurotrophin-3andneurotrophin-4withvaryingspecificities.Thep75NGFRplaysanimportantroleinneurotrophicfactorsignalingandhasbeenshowntomodulatethesusceptibilityofselectivecellularpopulationstoprogrammedcelldeath.ItisexpressedonmanyneuronalcellstypesincludingmanyembryonicformsandthereceptorcanbeusedtoisolateneuronalProgenitorcells.
      ProductInformation
      FormatPurified
      Control
      • WesternBlot:NGF-differentiatedPC12celllysate.
        Immunohistochemistry:Ratbraintissue.
      PresentationMousemonoclonalIgG1in0.02MPhosphatebuffer,pH7.6,0.25MNaClwith0.1%sodiumazide
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8oCfromdateofreceipt.
      Applications
      ApplicationAnti-NerveGrowthFactorReceptorAntibody,extracellular,clone192-IgGisanantibodyagainstNerveGrowthFactorReceptorforuseinIC,IH,IP,FUNC&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • AffectsFunction
      • WesternBlotting
      ApplicationNotesWesternBlot:
      1-5μg/mL(Non-reducingconditionsonly)wasusedonapreviouslot.

      InhitibitionAssay:
      InhibitiononNGFbinding{Chandler,1984}.

      Immunoprecipitation:
      5μg/mL,0.5%tritonX-100buffer;PC12positivecontrolwasusedonapreviouslot.

      Immunohistochemistry:
      1-5μg/mLonratspinalchord,ofapreviouslotwasused.Otherfixativesandmethodscanalsobeused.
      BIOLOGicalInformation
      Immunogenn-octoglucosidestABIlizedproteinscontainingp75receptor,whichwereisolatedfromplasmamembranesofPC-12cells(Chandleretal.,1984).
      EpitopeExtracellular
      Clone192-IgG
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificitySpecificfortheratlowaffinityNerveGrowthFactor-Receptor(p75),doesnotreactwithhumanormousep75.
      IsotypeIgG1
      SpeciesReactivity
      • Rat
      SpeciesReactivityNoteReactswithratp75protein.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryNervegrowthfactorreceptorcontainsanextracellulardomaincontainingfour40-aminoacidrepeatswith6cysteineresiduesatconservedpositionsfollowedbyaserine/threonine-richregion,asingletransmembranedomain,anda155-aminoacidcytoplasmicdomain.Thecysteine-richregioncontainsthenervegrowthfactorbindingdomain.
      GeneSymbol
      • NGFR
      • p75(NTR)
      • TNFRSF16
      • Gp80-LNGFR
      • CD271
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P08138#LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.
      SIZE:427aminoacids;45183Da
      SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1.InteractswithBEX1andNGFRAP1/BEX3.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      DOMAIN:SwissProt:P08138DeathdomainisresponsIBLeforinteractionwithRANBP9.
      PTM:N-andO-glycosylated.&O-linkedglycansconsistofGal(1-3)GalNAccoreelongatedby1or2NeuNAc.&Phosphorylatedonserineresidues.
      SIMILARITY:Contains1deathdomain.&Contains4TNFR-Cysrepeats.
      MolecularWeight75kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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