| Immunogen | Neuron-specificenolasefromhumanbrain. | 
| Clone | 5E2 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Humangammaneuronspecificenolase.Recognizesa45kDbandcorrespondingtogammaNSEonimmunoblotsofhumanbrainextracts. | 
| Isotype | IgG2a | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesoneofthethreeenolaseisoenzymesfoundinmammals.Thisisoenzyme,ahomodimer,isfoundinmatureneuronsandcellsofneuronalorigin.Aswitchfromalphaenolasetogammaenolaseoccursinneuraltissueduringdevelopmentinratsandprimates. | 
| GeneSymbol | - ENO2
 - NSE
 - Gamma-enolase
 - EC4.2.1.11
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P09104#Hasneurotrophicandneuroprotectivepropertiesonabroadspectrumofcentralnervoussystem(CNS)neurons.Binds,inacalcium-dependentmanner,toculturedneocorticalneuronsandpromotescellsurvival(Bysimilarity). COFACTOR:Magnesium.RequiredforcatalysisandforstABIlizingthedimer. SIZE:434aminoacids;47269Da SUBUNIT:Mammalianenolaseiscomposedof3isozymesubunits,alpha,betaandgamma,whichcanformhomodimersorheterodimerswhicharecell-typeanddevelopment-specific. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Cellmembrane(Bysimilarity).Note=Cantranslocatetotheplasmamembraneineitherthehomodimeric(alpha/alpha)orheterodimeric(alpha/gamma)form(Bysimilarity). TISSUESPECIFICITY:Thealpha/alphahomodimerisexpressedinembryoandinmostadulttissues.Thealpha/betaheterodimerandthebeta/betahomodimerarefoundinstriatedmuscle,andthealpha/gammaheterodimerandthegamma/gammahomodimerinneurons.DEVELOPMENTALSTAGE:Duringontogenesis,thereisatransitionfromthealpha/alphahomodimertothealpha/betaheterodimerinstriatedmusclecells,andtothealpha/gammaheterodimerinnervecells. SIMILARITY:SwissProt:P09104##Belongstotheenolasefamily. |