| Immunogen | SyntheticpeptidefromtheN-terminalCUBdomainofhumanneuropilin-1. | 
| Host | Rabbit | 
| Specificity | Neuropilin-1.Theimmunogensequencehaslowhomologywithneuropilin-2. | 
| SpeciesReactivity |  | 
| SpeciesReactivityNote | Itisexpectedthattheantibodywillalsoreactwithratandmouse. | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | NRP1isamembrane-boundcoreceptortoatyrosinekinasereceptorforbothvascularendothelialgrowthfactor(VEGF;MIM192240)andsemaphorin(seeSEMA3A;MIM603961)familymembers.NRP1playsversatilerolesinangiogenesis,axonguidance,cellsurvival,migration,andinvasion.[suppliedbyOMIM] | 
| GeneSymbol | - NRP1
 - neuropilin-1
 - DKFZp781F1414
 - VEGF165R
 - NRP
 - DKFZp686A03134
 - CD304
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:O14786#Thesolubleisoform2bindsVEGF-165andappearstoinhibititsbindingtocells.ItmayalsoinduceapoptosisbysequesteringVEGF-165.Maybindaswellvariousmembersofthesemaphorinfamily.Itsexpressionhasanaverseeffectonbloodvesselnumberandintegrity. SIZE:923aminoacids;103120Da SUBUNIT:HeterodimerwithNRP2(Probable).BindsPLXNB1. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted. TISSUESPECIFICITY:Theexpressionofisoforms1and2doesnotseemtooverlap.Isoform1isexpressedbythebloodvesselsofdifferenttissues.Inthedevelopingembryoitisfoundpredominantlyinthenervoussystem.Inadulttissues,itishighlyexpressedinheartandplacenta;moderatelyinlung,liver,skeletalmuscle,kidneyandpancreas;andlowinadultbrain.Isoform2isfoundinliverhepatocytes,kidneydistalandproximaltubules. SIMILARITY:SwissProt:O14786##Belongstotheneuropilinfamily.&Contains2CUBdomains.&Contains2F5/8typeCdomains.&Contains1MAMdomain. |