| Immunogen | Peptidecorrespondingtoaminoacids1-19fromratSynaptotagminI(Accession#P21107). | 
| Epitope | luminalpart | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | RecognizesSynaptotagminI,luminalpart.Theepitopedoesnotsharehomologywithanyotherknownproteins.
  SPECIESREACTIVITIES:Itisexpectedthattheantibodywillalsorecognizehuman.Otherspecieshavenotbeentested. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThesynaptotagminsareintegralmembraneproteinsofsynapticvesiclesthoughttoserveasCa(2+)sensorsintheprocessofvesiculartraffickingandexocytosis.CalciumbindingtosynaptotagminIparticipatesintriggeringneurotransmitterreleaseatthesynapse(Fernandez-Chaconetal.,2001[PubMed11242035]).[suppliedbyOMIM] | 
| GeneSymbol | - SYT1
 - DKFZp781D2042
 - SVP65
 - SytI
 - SYT
 - p65
 - P65
 - Synaptotagmin-1
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P21579#Mayhavearegulatoryroleinthemembraneinteractionsduringtraffickingofsynapticvesiclesattheactivezoneofthesynapse.Itbindsacidicphospholipidswithaspecificitythatrequiresthepresenceofbothanacidicheadgroupandadiacylbackbone.ACa(2+)-dependentinteractionbetweensynaptotagminandputativereceptorsforactivatedproteinkinaseChasalsobeenreported.ItcanbindtoatleastthreeadditionalproteinsinaCa(2+)-independentmanner;theseareneurexins,syntaxinandAP2. COFACTOR:Binds3calciumionspersubunit.TheionsareboundtotheC2domains(Bysimilarity). SIZE:422aminoacids;47573Da SUBUNIT:Homotetramer(Probable).InteractswithSTN2,SV2A,SV2B,SV2CandRIMS1.FormsacomplexwithSV2B,syntaxin1andSNAP25(Bysimilarity). SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesicle.Cytoplasmicvesicle,secretoryvesicle,chromaffingranule.Note=Synapticvesiclesandchromaffingranules. DOMAIN:SwissProt:P21579ThefirstC2domainmediatesCa(2+)-dependentphospholipidbinding.&ThesecondC2domainmediatesinteractionwithSV2AandSTN2(Bysimilarity). SIMILARITY:Belongstothesynaptotagminfamily.&Contains2C2domains. |