| Immunogen | Syntheticpeptide | 
| Host | Rabbit | 
| Specificity | NeuroD1(Neurogenicdifferentiationfactor1).ByWesternblottheantibodyrecognizesabandat~45kDaonhuman,ratandmousebrainlysate. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThisgeneencodesamemberoftheNeuroDfamilyofbasichelix-loop-helix(bHLH)transcriptionfactors.TheproteinformsheterodimerswithotherbHLHproteinsandactivatestranscriptionofgenesthatcontainaspecificDNAsequenceknownastheE-box.Itregulatesexpressionoftheinsulingene,andmutationsinthisgeneresultintypeIIdiabetesmellitus. | 
| GeneSymbol | - NEUROD1
 - NeuroD1
 - NeuroD
 - BETA2
 - BHF-1
 - NEUROD
 - NIDDM
 
  | 
| PurificationMethod | ImmunoAffinityPurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q13562#Differentiationfactorrequiredfordendritemorphogenesisandmaintenanceinthecerebellarcortex.Transcriptionalactivator.BindstotheinsulingeneE-box. SIZE:356aminoacids;39890Da SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.HeterodimerwithTCF3/E47.InteractswithRREB1. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Nucleus(Bysimilarity). PTM:Phosphorylated.Inisletcells,phosphorylatedonSer-274uponglucosestimulation;whichmayberequiredfornuclearlocalization.Inactivatedneurons,phosphorylatedonSer-335;whichpromotesdendriticgrowth(Bysimilarity). DISEASE:SwissProt:Q13562#DefectsinNEUROD1arethecauseofmaturityonsetdiabetesoftheyoungtype6(MODY6)[MIM:606394].MODY[MIM:606391]ischaracterizedbyanautosomaldominantmodeofinheritance,onsetduringyoungadulthoodandaprimarydefectininsulinsecretion. SIMILARITY:SwissProt:Q13562##Contains1basichelix-loop-helix(bHLH)domain. |