| Immunogen | Humanplacentalenzyme. | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | Cholinergicneuronsinbrainandcentralnervoussystems. | 
| SpeciesReactivity | - Human
 - Rat
 - Mouse
 - Bat
 - Feline
 - Monkey
 
  | 
| SpeciesReactivityNote | Human,Mouse,Rat,Monkey,Bat,Feline.ReactivitywithotherspecieshasnotbeenconfirmedwithIHC. | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesanenzymewhichcatalyzesthebiosynthesisoftheneurotransmitteracetylcholine.Thisgeneproductisacharacteristicfeatureofcholinergicneurons,andchangesintheseneuronsmayexplainsomeofthesymptomsofAlzheimerdisease.Mutationsinthisgeneareassociatedwithcongenitalmyasthenicsyndromeassociatedwithepisodicapnea.Multipletranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene,andsomeofthesevariantshavebeenshowntoencodemorethanoneisoform.[providedbyRefSeq].
  TranscriptVariant:Thisvariant(M)containsalternate5"exonM,usesanupstreamstartcodon,andencodesisoform2. | 
| GeneSymbol | - CHAT
 - ChAT
 - CHOACTase
 - CMS1A
 - CMS1A2
 
  | 
| PurificationMethod | Unpurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P28329#Catalyzesthereversiblesynthesisofacetylcholine(ACh)fromacetylCoAandcholineatcholinergicsynapses. SIZE:748aminoacids;82568Da DISEASE:SwissProt:P28329#DefectsinCHATarethecauseoffamilialinfantilemyastheniagravis2(FIMG2)[MIM:254210,254200];alsoknownasCMS-EA.FIMG2patientshavemyasthenicsymptomssincebirthorearlyinfancy,negativetestsforanti-AChRantibodies,andabruptepisodiccriseswithincreasedweakness,bulbarparalysis,andapneaprecipitatedbyundueexertion,fever,orexcitement.Inheritanceisautosomalrecessive. SIMILARITY:SwissProt:P28329##Belongstothecarnitine/cholineacetyltransferasefamily. |