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Millipore/09-187 | Anti-Ras Antibody, H Palmitoylated/09-187/100 µg
  • Millipore/09-187 | Anti-Ras Antibody, H Palmitoylated/09-187/100 µg

Millipore/09-187 | Anti-Ras Antibody, H Palmitoylated/09-187/100 µg

價(jià)格: ￥3324.00 市場價(jià): 5540.00
貨號: 09-187
品牌: Millipore
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    • Description
      CatalogueNumber09-187
      DescriptionAnti-RasAntibody,HPalmitoylated
      AlternateNames
      • N-rasproteinpart4
      • TransformingproteinN-Ras
      • neuroblastomaRASviral(v-ras)oncogenehomolog
      • v-rasneuroblastomaRASviraloncogenehomolog
      BackgroundInformationRasproteinsfunctionasGDP/GTP-regulatedbinaryswitchesinsignaltransductioncascadesthatcanleadtocellgrowth,proliferation,differentiation,orsurvival.Thisproteinundergoesacontinuouscycleofde-andre-palmitoylation,whichregulatesitsrapidexchangebetweentheplasmamembraneandtheGolgiapparatus.ThisRassuperfamilyhasatleastfivemajorbranchesthatincludeRas,Rho,Ran,Arf/Sar,Rab.Rasitselfhas3primaryisoforms(H-Ras,N-Ras,andK-Ras)thatdifferintheirapproximately20C-terminalaminoacids.TheyarecollectivelyreferredtoasRas.Initsactiveform,RasisboundtoGTP.Thiscausesaconformationalchangethatallowittointeractandbindtoseveraleffectormolecules,mostnotablythemembersoftheRaffamily,theRalGDSfamily,andPhosphoinositide3-kinases(PI3Kinase).RasthencleavesGTPtoGDPresultinginitsinactivation.Initsoncogenic,mutatedstate,RasisunabletohydrolyzeGTPtoGDP,thusstayinginanactivestateandactivatingnumerouspathways.
      ProductInformation
      FormatAffinityPurified
      PresentationAntigenaffinitypurifiedrabbitseruminbuffercontaining0.1MTris-Glycine(pH7.4),
      150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8oCfromdateofreceipt.
      Applications
      ApplicationAnti-RasAntibody,HPalmitoylateddetectslevelofRas&hasbeenpublished&validatedforuseinWB.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedsyntheticlinearpeptidecorrespondingtothehypervariableregionofRas,H,palmitoylated.
      Epitopehypervariableregion
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodydetectsthehypervariableregionRas,HPalmitoylated.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Chicken
      SpeciesReactivityNoteHuman.ExpectedtoreactwithRat,MouseandChickenbasedonsequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgenebelongstotheRasoncogenefamily,whosemembersarerelatedtothetransforminggenesofmammaliansarcomaretroviruses.Theproductsencodedbythesegenesfunctioninsignaltransductionpathways.TheseproteinscanbindGTPandGDP,andtheyhaveintrinsicGTPaseactivity.Thisproteinundergoesacontinuouscycleofde-andre-palmitoylation,whichregulatesitsrapidexchangebetweentheplasmamembraneandtheGolgiapparatus.MutationsinthisgenecauseCostellosyndrome,adisease
      characterizedbyincreasedgrowthattheprenatalstage,growthdeficiencyatthepostnatalstage,predispositiontotumorformation,mentalretardation,skinandmusculoskeletalabnormalities,distinctivefacialappearanceandcardiovascularabnormalities.Defectsinthisgeneareimplicatedinavarietyofcancers,includingbladdercancer,follicularthyroidcancer,andoralsquamouscellcarcinoma.Multipletranscriptvariants,whichencodedifferentisoforms,havebeenidentifiedforthisgene.[providedbyRefSeq].
      GeneSymbol
      • ALPS4
      • HRAS1
      • N-ras
      • NRAS1
      • OTTHUMP00000013879
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:RasproteinsbindGDP/GTPandpossessintrinsicGTPaseactivity.

      ENZYMEREGULATION:AlternatebetweenaninactiveformboundtoGDPandanactiveformboundtoGTP.Activatedbyaguaninenucleotide-exchangefactor(GEF)andinactivatedbyaGTPase-activatingprotein(GAP).

      SUBCELLULARLOCATION:Cellmembrane;Lipid-anchor;Cytoplasmicside.Golgiapparatusmembrane;Lipid-anchor.Note=ShuttlesbetweentheplasmamembraneandtheGolgiapparatus.

      PTM:PalmitoylatedbytheZDHHC9-GOLGA7complex.Acontinuouscycleofde-andre-palmitoylationregulatesrapidexchangebetweenplasmamembraneandGolgi.

      INVOLVEMENTINDISEASE:DefectsinNRASareacauseofjuvenilemyelomonocyticleukemia(JMML)[MIM:607785].JMMLisapediatricmyelodysplasticsyndromethatconstitutesapproximately30%ofchildhoodcasesofmyelodysplasticsyndrome(MDS)and2%ofleukemia.

      MutationswhichchangeAA12,13or61activatethepotentialofRastotransformculturedcellsandareimplicatedinavarietyofhumantumors.

      SEQUENCESIMILARITIES:BelongstothesmallGTPasesuperfamily.Rasfamily.

      MolecularWeight~48kDa(Speculatedtohavespecificityfordimerizedform)
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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