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Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg
  • Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg

Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg

價(jià)格: ￥4680.00 市場(chǎng)價(jià): 7800.00
貨號(hào): 07-371
品牌: Millipore
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    • Description
      CatalogueNumber07-371
      ReplacesMABE15
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-HistoneH2BAntibody
      AlternateNames
      • H2B
      • HistoneH2B
      • H2Bhistonefamily,memberQ
      • histone2
      • H2be
      • histonecluster2
      • H2be
      BackgroundInformationHistoneH2Btype3-B(UniProt:Q8N257;alsoknownasH2Btype12)isencodedbytheHIST3H2BBgene(GeneID:128312)inhuman.HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofchromatinineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichDNAiswrappedinrepeatingunits,callednucleosomes,whichlimitsDNAaccessibilitytothecellularmachineries,whichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.HistoneH2Bisoneofthemainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltail,H2Bisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.HistoneH2BcanbemonoubiquitinatedonLysine123byRAD6/UBC2-BRE1complextoformH2BK123Ub1complexthatgivesaspecifictagforepigenetictranscriptionalactivationandisalsoaprerequisiteforH3K4meandH3K79meformation.H2BK123ub1isreportedtomodulatestheformationofdouble-strandbreaksduringmeiosisandisarequiredforDNA-damagecheckpointactivation.HistoneH2BisphosphorylatedbySTE20toformH2BS10phduringprogressionthroughmeioticprophaseandmaybecorrelatedwithchromosomecondensation.HistoneH2BcanundergoacetylationbyGCN5,acomponentoftheSAGAcomplex,toformH2BK11acandH2BK16ac.AcetylationofN-terminallysinesandparticularlyformationofH2BK11acK16achasapositiveeffectontranscription.
      ProductInformation
      FormatPurified
      Control
      • AcidextractfromeithersodiumbutyrateorcolcemidtreatedHeLacells.
      PresentationPurifiedrabbitpolyclonalantibodyinbuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,with0.1%sodiumazideand30%glycerol.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      Applications
      ApplicationAnti-HistoneH2BAntibody,Cat.No.07-371,isahighlyspecificrabbitpolyclonalantibodythattargetsHistoneH2BandhasbeentestedinWesternBlotting.
      KeyApplications
      • WesternBlotting
      ApplicationNotesWesternBlottingAnalysis:1-2μg/mLfromarepresentativelotdetectedHistoneH2BinacidextractofHeLacellstreatedwitheithersodiumbutyrateorcolcemid.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingto9aminoacidsfromtheC-terminusofhumanHistoneH2Btype3-B.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisrabbitpolyclonalantibodydetectsHistoneH2Binhumanandchicken.Ittargetsanepitopewithin9aminoacidsfromtheC-terminusregion.
      IsotypeIgG
      SpeciesReactivity
      • Chicken
      • Human
      SpeciesReactivityNoteHuman,Chicken.PredictedtoreactwithYeast,Xenopusbasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.Transcriptsfromthisgenecontainapalindromicterminationelement.
      GeneSymbol
      • GL105
      • H2B
      • H2B-GL105
      • H2B.1
      • H2B.q
      • H2B/q
      • H2BFQ
      • MGC119802
      • MGC119804
      • MGC129733
      • MGC129734
      • OTTHUMP00000013920
      PurificationMethodProteinAchromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q8N257#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SIZE:126aminoacids;13908Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.&PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination.
      SIMILARITY:SwissProt:Q8N257##BelongstothehistoneH2Bfamily.
      MolecularWeight~17kDaobserved;13.91kDacalculated.Uncharacterizedbandsmaybeobservedinsomelysate(s).
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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