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Millipore/07-191 | Anti-phospho-Histone H2B (Ser14) Antibody/07-191/200 µL
  • Millipore/07-191 | Anti-phospho-Histone H2B (Ser14) Antibody/07-191/200 µL

Millipore/07-191 | Anti-phospho-Histone H2B (Ser14) Antibody/07-191/200 µL

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貨號(hào): 07-191
品牌: Millipore
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    • Description
      CatalogueNumber07-191
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-HistoneH2B(Ser14)Antibody
      AlternateNames
      • H2BS14P
      • HistoneH2B(phosphoS14)
      • H2Btype12
      • histone3
      • H2bb
      • histoneH2B
      • v
      BackgroundInformationModulationofchromatinstructureplaysanimportantroleintheregulationoftranscriptionineukaryotes.Thenucleosome,madeupoffourcorehistoneproteins(H2A,H2B,H3andH4),istheprimarybuildingblockofchromatin.Theamino-terminaltailsofcorehistonesundergovariousposttranslationalmodifications,includingacetylation,phosphorylation,methylationandubiquitination.Thesemodificationsoccurinresponsetovariousstimuliandhaveadirecteffectontheaccessibilityofchromatintotranscriptionfactorsand,therefore,ongeneexpression.
      ProductInformation
      FormatSerum
      Control
      • AcidextractedHL-60cellstreatedwithVP16
      PresentationRabbitantiserumpolyclonalIgGinbuffercontaining0.05%sodiumazideand30%glycerol.Liquidat-20°C.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIllityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationUseAnti-phospho-HistoneH2B(Ser14)Antibody(RabbitPolyclonalAntibody)validatedinELISA,ICC,IHC,WBtodetectphospho-HistoneH2B(Ser14)alsoknownasH2BS14P,HistoneH2B(phosphoS14).
      KeyApplications
      • ELISA
      • Immunocytochemistry
      • Immunohistochemistry
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenKLH-conjugated,syntheticpeptidecorrespondingtoaminoacids6-16ofhumanhistoneH2B(C-SAPAPKKG[pS]KK).
      EpitopeSer14
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesphospho-HistoneH2B(Ser14),Mr15kDa.
      IsotypeIgG
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteHuman.Broadspeciescross-reactivityexpectedbasedonsequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.Transcriptsfromthisgenecontainapalindromicterminationelement.
      GeneSymbol
      • HIST3H2BB
      Modifications
      • Phosphorylation
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q8N257#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SIZE:126aminoacids;13908Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.&PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination.
      SIMILARITY:SwissProt:Q8N257##BelongstothehistoneH2Bfamily.
      MolecularWeight15kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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