| Immunogen | KLH-conjugated,syntheticpeptidecorrespondingtoaminoacids129-137ofhumanHDAC4(C-EHQRKLERH) | 
| Host | Rabbit | 
| Specificity | HDAC4 | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.TheproteinencodedbythisgenebelongstoclassIIofthehistonedeacetylase/acuc/aphafamily.Itpossesseshistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.ThisproteindoesnotbindDNAdirectly,butthroughtranscriptionfactorsMEF2CandMEF2D.ItseemstointeractinamultiproteincomplexwithRbAp48andHDAC3. | 
| GeneSymbol | HDAC4HD4HDAC-AKIAA0288HDACAHA6116
 | 
| PurificationMethod | ProteinAchromatography | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P56524#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationviaitsinteractionwiththemyocyteenhancerfactorssuchasMEF2A,MEF2CandMEF2D. SIZE:1084aminoacids;119070Da
 SUBUNIT:InteractswithHDAC7(Bysimilarity).Homodimer.HomodimerizationviaitsN-terminaldomain.InteractswithMEF2CandNR2C1.Interactswitha14-3-3chaperoneproteininaphosphorylationdependentmanner.InteractswithBTBD14B(Bysimilarity).InteractswithJARID1B.
 SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Shuttlesbetweenthenucleusandthecytoplasm.Uponmusclecellsdifferentiation,itaccumulatesinthenucleiofmyotubes,suggestingapositiveroleofnuclearHDAC4inmuscledifferentiation.Theexporttocytoplasmdependsontheinteractionwitha14-3-3chaperoneproteinandisduetoitsphosphorylationatSer-246,Ser-467andSer-632byCaMK4.Thenuclearlocalizationprobablydependsonsumoylation.
 TISSUESPECIFICITY:Ubiquitous.
 DOMAIN:SwissProt:P56524Thenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasm.
 PTM:PhosphorylatedbyCaMK4atSer-246,Ser-467andSer-632.Phosphorylationatotherresiduesisrequiredfortheinteractionwith14-3-3.&SumoylationonLys-559ispromotedbytheE3SUMO-proteinligaseRANBP2,andpreventedbyphosphorylationbyCaMK4.
 SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily.
 | 
| MolecularWeight | 119kDa |