| Immunogen | KLH-conjugated,syntheticpeptide(REILSRRP(pS)YR)correspondingtoaminoacids125-135ofhumanCREB.Theimmunizingsequenceisidenticalinhumanandmouse.Clone10E9. | 
| Clone | clone10E9 | 
| Host | Mouse | 
| Specificity | RecognizesphosphorylatedCREBatMr46kDa.Mayalsorecognizep30andp38proteins,whichlikelycorrespondtophosphorylatedCREMandATF-1respectively,sincethetwoproteinssharesignificanthomologywiththephosphorylatedCREBimmunizingpeptide | 
| Isotype | IgG1κ | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThisgeneencodesatranscriptionfactorthatisamemberoftheleucinezipperfamilyofDNAbindingproteins.ThisproteinbindsasahomodimertothecAMP-responsiveelement,anoctamericpalindrome.Theproteinisphosphorylatedbyseveralproteinkinases,andinducestranscriptionofgenesinresponsetohormonalstimulationofthecAMPpathway.Alternatesplicingofthisgeneresultsintwotranscriptvariantsencodingdifferentisoforms. | 
| GeneSymbol |  | 
| Modifications |  | 
| PurificationMethod | Thiophilicadsoptionandsizeexclusionchromatography | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P16220#ThisproteinbindsthecAMPresponseelement(CRE),asequencepresentinmanyviralandcellularpromoters.CREBstimulatestranscriptiononbindingtotheCRE. SIZE:341aminoacids;36688Da SUBUNIT:BindsDNAasadimer.InteractsPPRC1andwithHTLV-1Tax-1. SUBCELLULARLOCATION:Nucleus. PTM:Stimulatedbyphosphorylation.PhosphorylationofbothSer-133andSer-142intheSCNregulatestheactivityofCREBandparticipatesincircADIanrhythmgeneration.PhosphorylationofSer-133allowsCREBBPandEP300binding(Bysimilarity).PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:P16220##BelongstothebZIPfamily.&Contains1bZIPdomain.&Contains1KID(kinase-inducIBLe)domain. | 
| MolecularWeight | 46kDa |