| Immunogen | Fusionprotein,humanb-gal-episialin/MUC1repeatdomain | 
| Clone | clone214D4 | 
| Host | Mouse | 
| Specificity | MUC1/episialin | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneisamemberofthemucinfamilyandencodesamembranebound,glycosylatedphosphoprotein.Theproteinisanchoredtotheapicalsurfaceofmanyepitheliabyatransmembranedomain,withthedegreeofglycosylationvaryingwithcelltype.Italsoincludesa20aavariablenumbertandemrepeat(VNTR)domain,withthenumberofrepeatsvaryingfrom20to120indifferentindividuals.Theproteinservesaprotectivefunctionbybindingtopathogensandalsofunctionsinacellsignalingcapacity.Overexpression,aberrantintracellularlocalization,andchangesinglycosylationofthisproteinhavebeenassociatedwithcarcinomas.Multiplealternativelysplicedtranscriptvariantsthatencodedifferentisoformsofthisgenehavebeenreported,butthefull-lengthnatureofonlysomehasbeendetermined. | 
| GeneSymbol | - MUC1
 - MUC1/ZD
 - MUC-1/X
 - PEMT
 - MUC-1
 - Episialin
 - episialin
 - MUC-1/SEC
 - PUM
 - EMA
 - PEM
 - H23AG
 - MAM6
 - CD227
 
  | 
| PurificationMethod | ProteinGChromatography | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P15941#Isoform7behavesasareceptorandbindsthesecretedisoform5.Thebindinginducesthephosphorylationoftheisoform7,alterscellularmorphologyandinitiatescellsignaling.CanbindtoGRB2adapterprotein. SIZE:1255aminoacids;122072Da SUBUNIT:Thecleavedform(onlytheisoform1)ofMUC1formsatightheterodimerwiththereleasedC-terminalpeptide(whichisfirstsecretedtobeextracellular). SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform5:Secreted.&Isoform9:Secreted. TISSUESPECIFICITY:ExpressedonductalepithelialcellsandonactivatedT-cells.Aberrantlyglycosylatedformsexpressedinhumanepithelialtumors,suchasbreastorovariancancerandalsoinnon-epithelialtumorcells.Isoform7expressedonlyintumoralcells. PTM:Highlyglycosylated(N-andO-linkedcarbohydratesandsialicacid).Inthe20aminoacidtandemrepeatpositions5(Ser),6(Thr),14(Thr),15(Ser)and19(Thr)areO-glycosylated(GalNAc).TheaveragedensityofO-glycosylatedsiteswithinrepeatpeptidesvarieswithcelldifferentiationfromabout50%inlactation-associatedMUC1toover90%inavarietyofbreastcancercells.&Isoform1andisoform7undergoestransphosphorylationonserineandtyrosineresidues. SIMILARITY:SwissProt:P15941##Contains1SEAdomain. | 
| MolecularWeight | nonegiven |